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{{Taxobox
| color = lightgreen
| name = Khat
| status = LR/lc
| image = Catha edulis.jpg
| image_caption = ''Catha edulis''
| regnum = [[Plant]]ae
| divisio = [[flowering plant|Magnoliophyta]]
| classis = [[Dicotyledon|Magnoliopsida]]
| ordo = [[Celastrales]]
| familia = [[Celastraceae]]
| genus = '''''Catha'''''
| species = '''''C. edulis'''''
| binomial = ''Catha edulis''
| binomial_authority = (Vahl) Forssk. ex Endl.
}}
'''Khat''' (''Catha edulis'', family [[Celastraceae]], [[Ge'ez alphabet|Ge'ez]] ጫት ''č̣āt''; [[Arabic alphabet|Arabic]]: قات; [[International Phonetic Alphabet|IPA]]: {{IPA|[kat]}}), and also known as '''qat''', '''gat''', '''chat''', and '''miraa'''), is a [[flowering plant]] native to tropical [[East Africa]] and the [[Arabian Peninsula]]. Believed to have originated in [[Ethiopia]], it is a [[shrub]] or small [[tree]] growing to 5–8 m tall, with [[evergreen]] [[leaf|leaves]] 5–10 cm long and 1–4 cm broad. The [[flower]]s are produced on short axillary [[cyme]]s 4–8 cm long, each flower small, with five white petals. The [[fruit]] is an oblong three-valved capsule containing 1–3 [[seed]]s.<br>
Khat contains the alkaloid [[cathinone]], an [[amphetamine]]-like [[stimulant]] which causes excitement and [[Euphoria (emotion)|euphoria]]. In [[1980]] the World Health Organization classified khat as a drug of abuse that can produce mild to moderate psychological dependence, and the plant has been targeted by anti-drug organizations like the [[Drug Enforcement Administration|DEA]].<ref>{{cite web|url=http://www.dea.gov/slideshow/july2006.htm|title="2006 in Pictures"|author=DEA}}</ref> It is a controlled/illegal substance in many North American countries because it is believed the smuggling of khat funds terrorists organizations in the Middle East.<ref>{{cite web|url=http://www.fbi.gov/congress/congress03/mccraw052003.htm|title="International Drug Trafficking and Terrorism"|author=FBI}}</ref>
==History==
The origins of khat are often argued. Many believe that they are [[Ethiopian]] in nature, from where it spread to the hillsides of East Africa and [[Yemen]]. Others believe that khat originated in Yemen before spreading to Ethiopia and nearby countries. [[Sir Richard Burton]] (''First Footsteps in East Africa'', 1856) explains that khat was introduced to the Yemen from Ethiopia in the 15th century. There is also evidence to suggest this may have occurred as early as the 13th century. Through botanical analysis, Revri (1983) supports Yemen origins of the plant.<ref> [https://bora.uib.no/bitstream/1956/858/6/paper+1.pdf] </ref> From Ethiopia and Yemen the trees spread to [[Kenya]], [[Somalia]], [[Malawi]], [[Uganda]], [[Tanzania]], [[Arabia]], the [[Congo]], what are now [[Zimbabwe]] and [[Zambia]], and South Africa.<ref>[http://alb2c3,com/drugs/khat1.htm "Khat Information"]</ref> The earliest recorded use of khat medically is believed to be within the [[New Testament]].<ref>http://apt.rcpsych.org/cgi/content/full/9/6/456 "Adverse effects of Khat: A review" [[01 December]] [[2006]] </ref> The ancient Egyptians considered the khat plant a "divine food" which was capable of releasing humanity's divinity. The Egyptians used the plant for more than its stimulating effects. They used it as a metamorphic process and transcended into "apotheosis." Thus, the human being was made god-like.<ref> [http://psychonaut.com] </ref>
In 1854, the Malay writer [[Abdullah bin Abdul Kadir]] noted that the custom of chewing Khat was prevalent in [[Al Hudaydah]] in Yemen: "I observed a new peculiarity in this city—everyone chewed leaves as goats chew the cud. There is a type of leaf, rather wide and about two fingers in length, which is widely sold, as people would consume these leaves just as they are; unlike betel leaves, which need certain condiments to go with them, these leaves were just stuffed fully into the mouth and munched. Thus when people gathered around, the remnants from these leaves would pile up in front of them. When they spat, their saliva was green. I then queried them on this
matter: ‘What benefits are there to be gained from eating these leaves?’ To which they replied, ‘None whatsoever, it’s just another expense for us as we’ve grown accustomed to it’. Those who consume these leaves have to eat lots of ghee and honey, for they would fall ill otherwise. The leaves are known as Kad."<ref>Ché-Ross, Raimy. MUNSHI ABDULLAH'S VOGAGE TO MECCA: A PRELIMINARY INTRODUCTION AND ANNOTATED TRANSLATION. Indonesia & the Malay World; Jul2000, Vol. 28 Issue 81, p196</ref>
==Cultivation and uses==
[[Image:Deakhat.jpg|thumb|300px|Bundles of khat, captured by the DEA in July, 2006]]
Khat has been grown for use as a stimulant for centuries in the [[Horn of Africa]] and the [[Arabian Peninsula]]. There, chewing khat predates the use of [[coffee]] and is used in a similar social context. Its fresh leaves and tops are chewed or, less frequently, dried and consumed as tea, in order to achieve a state of euphoria and stimulation. Due to the availability of rapid, inexpensive air transportation, the drug has been reported in [[England]], [[Rome]], [[Amsterdam]], [[Canada]], [[Australia]], [[New Zealand]]<ref>http://www.nzherald.co.nz/section/story.cfm?c_id=1&objectid=10415187&ref=rss</ref> and the [[United States]]. The public has become more aware of this exotic drug through media reports pertaining to the [[United Nations]] mission in [[Somalia]], where khat use is widespread, and its role in the [[Persian Gulf]]. The khat plant is known by a variety of names, such as qat in Yemen, chat in [[Ethiopia]], jaad in Somalia and miraa in Kenya and Tanzania.
Khat use has traditionally been confined to the regions where khat is grown, because only the fresh leaves have the desired stimulating effects. In recent years improved roads, off-road motor vehicles and air transport have increased the global distribution of this perishable commodity. Traditionally, khat has been used as a socializing drug, and this is still very much the case in Yemen where khat-chewing is a predominantly male habit.<ref name="Sanaa">[http://news.bbc.co.uk/2/hi/programmes/from_our_own_correspondent/6530453.stm Yemen's khat habit soaks up water] by Alex Kirby. [[bbb.co.uk]]. Written [[2007]]-[[April 7|4-7]]. Accessed [[2007]]-[[April 8|4-8]].</ref> In other countries, khat is consumed largely by single individuals and at parties. It is mainly a recreational drug in the countries which grow khat, though it may also be used by farmers and laborers for reducing physical fatigue and by drivers and students for improving attention. This is similar to the use of the [[coca]] leaf in [[South America]].Women also chew Khat in Yemen. They have their own Saloons for chewing Khat. It is also noted that on weekends, husbands and wives chew Khat. Children start chewing Khat at the age of 10.
Khat is used for its mild euphoric and stimulating effects. It has [[anorectic]] effects. It is used by Christians, Jews, and Muslims, though the [[Ethiopian Orthodox Tewahedo Church]] (along with its [[Eritrean Orthodox Tewahdo Church|Eritrean counterpart]]) has forbidden Christians from using it due to its stimulating effects. In Yemen it is so popular that 40% of the country's water supply goes towards irrigating it, with the percentage increasing by about 10% to 15% every year.<ref name="Sanaa">a</ref> The water supply of [[Sanaa]] is so threatened by the crop that government officials have even proposed relocating large portions of the city's population to the coast of the [[Red Sea]].<ref name="Sanaa">a</ref>
In Somalia, the [[Supreme Islamic Courts Council]], which took control of much of the country in 2006, banned khat during [[Ramadan]], sparking street protests in [[Kismayo]]. In November 2006, Kenya banned all flights to Somalia, citing security concerns, prompting protests by Kenyan khat growers. The Kenyan MP from Ntonyiri, [[Meru North District]] stated that local land had been specialized in khat cultivation, that 20 tons worth US$800,000 were shipped to Somalia daily and that a flight ban could devastate the local economy.<ref>[http://news.bbc.co.u
k/2/hi/africa/6142688.stm "Kenya bans all flights to Somalia"], ''[[BBC News]]'', [[13 November]] [[2006]]</ref> With the surprise victory of the Provisional Government backed by Ethiopian forces in the end of December 2006, khat has returned to the streets of Mogadishu, though Kenyan traders have noted demand has not yet returned to pre-ban levels.<ref> It is widley believed that Somali militia fighters loyal to Mohamed Farrah Aidid were under the influence of khat during the first battle of Mogadishu.[http://news.yahoo.com/s/nm/20070102/od_uk_nm/oukoe_uk_somalia_conflict_khat "Somali Islamists are gone -- so "khat" is back!"], ''[[Reuters]]'', [[2 January]] [[2007]]</ref>
== Chemistry/pharmacology ==
The stimulant effect of the plant was originally attributed to "katin", [[cathine]], a [[phenethylamine]]-type substance isolated from the plant. However, the attribution was disputed by reports showing the plant extracts from fresh leaves contained another substance more behaviorally active than cathine. In 1975, the related alkaloid [[cathinone]] was isolated, and its [[absolute configuration]] was established in [[1978]]. Cathinone is not very stable and breaks down to produce cathine and [[phenylpropanolamine|norephedrine]]. These chemicals belong to the [[phenylpropanolamine|PPA (phenylpropanolamine)]] family, a subset of the [[phenethylamine]]s related to [[amfetamine|amphetamines]] and the [[catecholamine]]s [[epinephrine]] and [[norepinephrine]].<ref>{{cite web|url=http://www.drugs.com/npp/khat.html|title=Complete Khat Info|author=Drugs.com|date=01.01.07}}</ref>
Both of khat's major active ingredients -cathine and cathinone- are phenylalklamines, meaning they are in the same class of chemicals as amphetamines. In fact, cathinone and cathine have a very similar molecular structure to amphetamine.<ref>{{cite web|url=http://apt.rcpsych.org/cgi/content/full/9/6/456|title=Adverse Effects of Khat: A Review}}</ref>
When khat leaves dry, the more potent chemical, cathinone, evaporates within 48 hours leaving behind the milder Schedule IV chemical, cathine. Thus, harvesters transport khat by packaging the leaves and stems in plastic bags or wrapping them in banana leaves to preserve their moisture and keep the cathinone potent. It is also common for them to frequently sprinke the plant with water or use refrigeration during transportation.
When the leaves are chewed, cathine and cathinone are released and absorbed through the mucous membranes of the mouth and the lining of the stomach. The action of cathine and cathinone on the reuptake of epinephrine and norepinephrine has been demonstrated in lab animals, showing that one or both of these chemicals cause the body to recycle these neurotransmitters more slowly, resulting in the wakefulness and insomnia associated with khat use.<ref>{{cite web|url=www.ncbi.nlm.nih.gov/entrez|title=Biochemical Effects of Catha edulis, Cathine and Cathinone on Adrenocortical Functions}}</ref>
Receptors for serotonin show a high affinity for cathinone suggesting that this chemical is responsible for feelings of euphoria associated with chewing khat. In mice, cathinone produces the same types of nervous pacing or repetitive scratching behaviors associated with amphetamines.<ref>{{cite web|url=www.ncbi.nlm.nih.gov/entrez|title=Behavioral Effects of Cathinone}}</ref> The effects of cathinone peak after 15 to 30 minutes with nearly 98% of the substance metabolized into norephedrine by the liver.<ref>{{cite web|url=http://apt.rcpsych.org/cgi/content/full/9/6/456|title=Adverse Effects of Khat: A Review}}</ref>
Cathine is somewhat less understood, being believed to act upon the adrenergenic receptors causing the release of epinephrine and norepinephrine.<ref>{{cite web|url=http://humrep.oxfordjournals.org/content/abstract/del454v1|title=Cathin, an Amphetamine Related Compound, Acts on Mammalian Spermatozoa via Adrenergic Receptors in a Capacitation State-Dependent Manner}}</ref> It has a half-life of about 3 hours in humans.
==Effects==
Khat consumption induces mild [[Euphoria (emotion)|euph
oria]] and excitement. Individuals become very talkative under the influence of the drug and may appear to be unrealistic and emotionally unstable. Khat can induce [[mania|manic]] behaviors and hyperactivity. Khat is an effective [[anorectic]] and its use also results in [[constipation]]. Dilated [[pupil]]s (mydriasis), which are prominent during khat consumption, reflect the sympathomimetic effects of the drug, which are also reflected in increased heart rate and blood pressure. A state of drowsy [[hallucination]]s ([[hypnagogia|hypnagogic hallucination]]s) may result coming down from khat use as well. [[Withdrawal]] [[symptom]]s that may follow prolonged khat use include lethargy, mild [[clinical depression|depression]], [[nightmare]]s, and slight [[tremor]]. Long term use can precipitate the following effects: negative impact on liver function, permanent tooth darkening (of a greenish tinge), susceptibility to ulcers, and diminished sex drive. Khat is usually not an addictive drug, although there are some people who cannot stay without it for more than 4-5 days. They feel tired and have difficulty concentrating.<ref>{{cite web|url=http://www.drugs.com/npp/khat.html|title=Complete Khat Info|author=Drugs.com|date=01.01.07}}</ref>
However, a recent British study found khat to be less dangerous than tobacco and alcohol.<ref>{{cite web|url=http://news.bbc.co.uk/1/shared/bsp/hi/pdfs/31_07_06_drugsreport.pdf|title=Drug classification: making a hash of it?|author=House of Commons}}</ref>
== User population ==
It is estimated that several million people are frequent users of khat. Many of the users originate from countries between [[Sudan]] and [[Madagascar]] and in the southwestern part of the [[Arabian Peninsula]], especially [[Yemen]]. In Yemen, 60% of the males and 35% of the females were found to be khat users who had chewed daily for long periods of their life. The traditional form of khat chewing in Yemen involves only male users; khat chewing by females is less formal and less frequent. In [[Saudi Arabia]], the cultivation and consumption of khat are forbidden, and the ban is strictly enforced. The ban on khat is further supported by the clergy on the grounds that the Qur'an forbids anything that is harmful to the body. This is in sharp contrast to the opinions of the clergy in Yemen. In Somalia, 61% of the population reported that they do use khat, 18% report habitual use, and 21% are occasional users. {{Fact|date=February 2007}}
== Control status ==
===World===
In [[1965]], the [[World Health Organization]] Expert Committee on Dependence-producing Drugs' ''Fourteenth Report'' noted, "The Committee was pleased to note the resolution of the [[Economic and Social Council]] with respect to khat, confirming the view that the abuse of this substance is a regional problem and may best be controlled at that level" [http://www.unodc.org/unodc/en/bulletin/bulletin_1965-01-01_4_page007.html]. For this reason, khat was not Scheduled under the [[Single Convention on Narcotic Drugs]]. In [[1980]] the World Health Organization classified khat as a drug of abuse that can produce mild to moderate psychic dependence.
===Australia===
In [[Australia]], the importation of khat is controlled under the Customs (Prohibited Imports) Regulations. Individual users may apply for several required licenses to import up to 5 kg per month for personal use (primarily immigrants from the Horn of Africa). In 2003, the total number of khat annual permits was 294 and the total number of individual khat permits was 202.
{{quotation|There are two types of import permits. The single use Permit to Import can be used only once and you must request a new permit for each time you wish to import khat. Annual Permits are labeled as such and consist of two pages. Annual Permits allow you to import up to 5 kg once a month for up to twelve months.|{{Fact|date=April 2007}}}}
===Canada===
In [[Canada]], khat is a controlled substance under Schedule IV of the [[Controlled Drugs and Substances Act]] (CDSA). Every person who seeks or obtains the substance with
out disclosing authorization to obtain such substances 30 days prior to obtaining another prescription from a practitioner is guilty of an indictable offence and liable to imprisonment for a term not exceeding eighteen months, where the subject-matter of the offence is a substance included in Schedule IV '''or''' is guilty of an offence punishable on summary conviction and liable for a first offence, to a fine not exceeding one thousand dollars or to imprisonment for a term not exceeding six months, or to both, and for a subsequent offence, to a fine not exceeding two thousand dollars or to imprisonment for a term not exceeding one year, or to both. [http://www.rcmp-grc.gc.ca/crimint/drugs_2002_e.htm#khat] [http://lois.justice.gc.ca/en/C-38.8/229593.html#rid-229600]
===France===
Khat is prohibited in [[France]] as a stimulant.<ref>{{cite web|url=http://www.drugs.com/npp/khat.html|title=Complete Khat Info|author=Drugs.com|date=01.01.07}}</ref>
===Germany===
In [[Germany]], Cathine is a controlled substance, and ownership and sale of the plant is illegal. Similar levels of control exist throughout most other European countries.
===Hong Kong===
In Hong Kong, Cathine & Cathinone are regulated under Schedule 1 of Hong Kong's Chapter 134 ''Dangerous Drugs Ordinance''. It can only be used legally by health professionals and for university research purposes. The substance can be given by pharmacists under a prescription. Anyone who supplies the substance without prescription can be fined $10,000(HKD). The penalty for trafficking or manufacturing the substance is a $5,000,000 (HKD) fine and life imprisonment. Possession of the substance for consumption without license from the Department of Health is illegal with a $1,000,000 (HKD) fine and/or 7 years of jail time.
===Israel===
Khat is still used by some people of Yemeni origins. The leaves, as well as the cathonine extract pill called 'Hagiggat' (a joining of the Hebrew word Hagiga (party), and Gat (khat)), are currently illegal.
===Norway===
Khat is classified as a narcotic drug and is illegal to use, sell and possess. Most users are Somali immigrants and khat is smuggled from [[the Netherlands]] and England.<ref>{{cite web|url=http://www.nova.no/index.gan?objid=11648&subid=0&language=1|title=NOVA paper 1/06|date=16.03.07}}</ref>
===Somalia===
On November 17, 2006 the usage and distribution of khat was made illegal according to Somali Islamists in areas they control.<ref>[http://news.bbc.co.uk/2/hi/africa/6157216.stm]</ref> In Somalia, the [[Supreme Islamic Courts Council]], which took control of much of the country in 2006, banned khat during [[Ramadan]], sparking street protests in [[Kismayo]]. In November 2006, Kenya banned all flights to Somalia, citing security concerns, prompting protests by Kenyan khat growers. The Kenyan MP from Ntonyiri, [[Meru North District]] stated that local land had been specialized in khat cultivation, that 20 tons worth US$800,000 were shipped to Somalia daily and that a flight ban could devastate the local economy.<ref>[http://news.bbc.co.uk/2/hi/africa/6142688.stm "Kenya bans all flights to Somalia"], ''[[BBC News]]'', [[13 November]] [[2006]]</ref> With the surprise victory of the Provisional Government backed by Ethiopian forces in the end of December 2006, khat has returned to the streets of Mogadishu, though Kenyan traders have noted demand has not yet returned to pre-ban levels.<ref>[http://news.yahoo.com/s/nm/20070102/od_uk_nm/oukoe_uk_somalia_conflict_khat "Somali Islamists are gone -- so "khat" is back!"], ''[[Reuters]]'', [[2 January]] [[2007]]</ref>
===Sweden===
As in Norway, khat is classified as a narcotic drug in [[Sweden]] and is illegal to use, sell and possess. According to the police, most users are Somali immigrants and most khat is smuggled in from [[the Netherlands]] and England. For more information, see the [http://www.polisen.se/inter/nodeid=35071&pageversion=1.jsp Swedish police website on khat] (text in Swedish).
===Switzerland===
Khat is prohibited in [[Switzerland]] as a stimulant.<ref>{{cite web|ur
l=http://www.drugs.com/npp/khat.html|title=Complete Khat Info|author=Drugs.com|date=01.01.07}}</ref>
===United Kingdom===
Khat is not a controlled substance in the United Kingdom. Because of this, and because of khat's short shelf life, the UK serves as a main gateway for khat being sent by air to North America.[http://www.cbc.ca/canada/toronto/story/2007/01/26/tor-khat.html]
Khat is used by members of the Somali and Yemeni community (mainly men), which is concentrated in [[London]], [[Birmingham]], [[Bristol]], [[Cardiff]], [[Manchester]] and [[Sheffield]]. It is currently legal, although there are calls from some sections of the Somali community for it to be banned. In the [[United Kingdom|UK]], Cathine and Cathinone are [[Misuse of Drugs Act 1971#Class C drugs|Class C drugs]]. The plant '''''Catha edulis''''' is uncontrolled.
===United States===
In the [[United States]], Cathine is in Schedule IV and cathinone is in Schedule I of the U.S. [[Controlled Substance Act]]. The [[1993]] [[Drug Enforcement Administration|DEA]] rule placing cathinone in Schedule I noted that it was effectively also banning khat:
{{quotation|Cathinone is the major psychoactive component of the plant Catha edulis (khat). The young leaves of khat are chewed for a stimulant effect. Enactment of this rule results in the placement of any material which contains cathinone into Schedule I.}}
In July, 2006, the DEA executed '''Operation Somalia Express''', an 18-month investigation which resulted in the coordinated takedown of a 44-member international trafficking organization responsible for smuggling more than 25 tons of khat (estimated by the DEA to be worth more than $10 million) from the [[Horn of Africa]] to the United States.
The indictment represents the largest khat-trafficking prosecution in United States history.
A large of amount of khat was recently discovered in Smyrna, Delaware. Smyrna police on Friday, March 16, 2007 raided a storage room at Sentinel Self Storage after receiving information that a man was storing illegal drugs at that location. Upon making entry into the room, police say they seized 704¼ pounds of suspected Khat, with an estimated street value of approximately $211,275.<ref>{{cite web|url=http://www.dea.gov/slideshow/july2006.htm|title="2006 in Pictures"|author=DEA}}</ref>
On May 17, 2007 200 lbs. of Khat was found in a self storage facility in Louisville, KY.
==Trivia==
* The word "qat" is well known to [[Scrabble]] players as a way to use the Q when no U is available.
* Smuggling of the plant known as Qat (khat) is the main reason British nationals require consular assistance in Canada. [http://www.fco.gov.uk/servlet/Front?pagename=OpenMarket/Xcelerate/ShowPage&c=Page&cid=1007029390590&a=KCountryAdvice&aid=1013618387099]
== See also ==
[[Qat in Yemen]]
==References==
* {{IUCN2006|assessors=Hilton-Taylor|year=1998|id=34617|title=Catha edulis|downloaded=12 May 2006}}
* "Somali Islamists are gone -- so "khat" is back!", Reuters, January 2 2007
* [[Dale Pendell]], ''Pharmakodynamis: Stimulating Plants, Potions and Herbcraft: Excitantia and Empathogenica'', San Francisco: Mercury House, 2002.
== Notes ==
<!-- This article uses [[Wikipedia:Footnotes]]. Please use this format when adding references to material in the article. External links added directly to this section will be swiftly deleted without notice. -->
<div class="references-small">
<references />
</div>
==External links==
*[http://www.freshgat.com/servlet/the-38/how-to-chew-khat/Detail How to chew qat]
*[http://news.bbc.co.uk/2/shared/spl/hi/picture_gallery/07/africa_growing_khat/html/1.stm BBC News: In pictures... growing khat]
*[http://www.drugs.com/npp/khat.html Drugs.com, Complete Khat Information]
*[http://www.esquire.com/features/articles/2006/060807_mfe_September_06_Quest__1.html Esquire "High in Hell"]
*[http://www.erowid.org/plants/khat/khat.shtml Erowid Khat Vault]
*[http://www.freshgat.com/servlet/the-template/faq/Page Growing Catha Edulis (Khat)]
*[http://news.bbc.co.uk/2/hi/africa/4145400.stm BBC: Getting to grips with khat in Soma
liland]
*[http://news.bbc.co.uk/1/hi/uk/4615415.stm BBC: Harmless habit or dangerous drug?]
*[http://www.tga.gov.au/docs/html/khatapp.htm Australian Government : Therapeutic Goods Administration Khat Importation Kit]
*[http://www.startribune.com/484/story/577963.html Dozens Arrested Nationwide in Drug Case]
*[http://historyofalcoholanddrugs.typepad.com/alcohol_and_drugs_history/qat/index.html Qat news page] - [[Alcohol and Drugs History Society]] (ADHS)
**[http://historyofalcoholanddrugs.typepad.com/alcohol_and_drugs_history/khat/index.html Khat news page] (ADHS)
*[http://seattletimes.nwsource.com/html/localnews/2003199353_khat15m.html Seattle arrest - Khat and the Somalian community]
*[http://villagevoice.com/news/0647,gardiner,75103,2.html Village Voice article on khat]
[[Category:Amphetamines]]
[[Category:Celastraceae]]
[[Category:Flora of South Africa]]
[[Category:Trees of Africa]]
[[Category:Herbal and fungal stimulants]]
| color = lightgreen
| name = Khat
| status = LR/lc
| image = Catha edulis.jpg
| image_caption = ''Catha edulis''
| regnum = [[Plant]]ae
| divisio = [[flowering plant|Magnoliophyta]]
| classis = [[Dicotyledon|Magnoliopsida]]
| ordo = [[Celastrales]]
| familia = [[Celastraceae]]
| genus = '''''Catha'''''
| species = '''''C. edulis'''''
| binomial = ''Catha edulis''
| binomial_authority = (Vahl) Forssk. ex Endl.
}}
'''Khat''' (''Catha edulis'', family [[Celastraceae]], [[Ge'ez alphabet|Ge'ez]] ጫት ''č̣āt''; [[Arabic alphabet|Arabic]]: قات; [[International Phonetic Alphabet|IPA]]: {{IPA|[kat]}}), and also known as '''qat''', '''gat''', '''chat''', and '''miraa'''), is a [[flowering plant]] native to tropical [[East Africa]] and the [[Arabian Peninsula]]. Believed to have originated in [[Ethiopia]], it is a [[shrub]] or small [[tree]] growing to 5–8 m tall, with [[evergreen]] [[leaf|leaves]] 5–10 cm long and 1–4 cm broad. The [[flower]]s are produced on short axillary [[cyme]]s 4–8 cm long, each flower small, with five white petals. The [[fruit]] is an oblong three-valved capsule containing 1–3 [[seed]]s.<br>
Khat contains the alkaloid [[cathinone]], an [[amphetamine]]-like [[stimulant]] which causes excitement and [[Euphoria (emotion)|euphoria]]. In [[1980]] the World Health Organization classified khat as a drug of abuse that can produce mild to moderate psychological dependence, and the plant has been targeted by anti-drug organizations like the [[Drug Enforcement Administration|DEA]].<ref>{{cite web|url=http://www.dea.gov/slideshow/july2006.htm|title="2006 in Pictures"|author=DEA}}</ref> It is a controlled/illegal substance in many North American countries because it is believed the smuggling of khat funds terrorists organizations in the Middle East.<ref>{{cite web|url=http://www.fbi.gov/congress/congress03/mccraw052003.htm|title="International Drug Trafficking and Terrorism"|author=FBI}}</ref>
==History==
The origins of khat are often argued. Many believe that they are [[Ethiopian]] in nature, from where it spread to the hillsides of East Africa and [[Yemen]]. Others believe that khat originated in Yemen before spreading to Ethiopia and nearby countries. [[Sir Richard Burton]] (''First Footsteps in East Africa'', 1856) explains that khat was introduced to the Yemen from Ethiopia in the 15th century. There is also evidence to suggest this may have occurred as early as the 13th century. Through botanical analysis, Revri (1983) supports Yemen origins of the plant.<ref> [https://bora.uib.no/bitstream/1956/858/6/paper+1.pdf] </ref> From Ethiopia and Yemen the trees spread to [[Kenya]], [[Somalia]], [[Malawi]], [[Uganda]], [[Tanzania]], [[Arabia]], the [[Congo]], what are now [[Zimbabwe]] and [[Zambia]], and South Africa.<ref>[http://alb2c3,com/drugs/khat1.htm "Khat Information"]</ref> The earliest recorded use of khat medically is believed to be within the [[New Testament]].<ref>http://apt.rcpsych.org/cgi/content/full/9/6/456 "Adverse effects of Khat: A review" [[01 December]] [[2006]] </ref> The ancient Egyptians considered the khat plant a "divine food" which was capable of releasing humanity's divinity. The Egyptians used the plant for more than its stimulating effects. They used it as a metamorphic process and transcended into "apotheosis." Thus, the human being was made god-like.<ref> [http://psychonaut.com] </ref>
In 1854, the Malay writer [[Abdullah bin Abdul Kadir]] noted that the custom of chewing Khat was prevalent in [[Al Hudaydah]] in Yemen: "I observed a new peculiarity in this city—everyone chewed leaves as goats chew the cud. There is a type of leaf, rather wide and about two fingers in length, which is widely sold, as people would consume these leaves just as they are; unlike betel leaves, which need certain condiments to go with them, these leaves were just stuffed fully into the mouth and munched. Thus when people gathered around, the remnants from these leaves would pile up in front of them. When they spat, their saliva was green. I then queried them on this
matter: ‘What benefits are there to be gained from eating these leaves?’ To which they replied, ‘None whatsoever, it’s just another expense for us as we’ve grown accustomed to it’. Those who consume these leaves have to eat lots of ghee and honey, for they would fall ill otherwise. The leaves are known as Kad."<ref>Ché-Ross, Raimy. MUNSHI ABDULLAH'S VOGAGE TO MECCA: A PRELIMINARY INTRODUCTION AND ANNOTATED TRANSLATION. Indonesia & the Malay World; Jul2000, Vol. 28 Issue 81, p196</ref>
==Cultivation and uses==
[[Image:Deakhat.jpg|thumb|300px|Bundles of khat, captured by the DEA in July, 2006]]
Khat has been grown for use as a stimulant for centuries in the [[Horn of Africa]] and the [[Arabian Peninsula]]. There, chewing khat predates the use of [[coffee]] and is used in a similar social context. Its fresh leaves and tops are chewed or, less frequently, dried and consumed as tea, in order to achieve a state of euphoria and stimulation. Due to the availability of rapid, inexpensive air transportation, the drug has been reported in [[England]], [[Rome]], [[Amsterdam]], [[Canada]], [[Australia]], [[New Zealand]]<ref>http://www.nzherald.co.nz/section/story.cfm?c_id=1&objectid=10415187&ref=rss</ref> and the [[United States]]. The public has become more aware of this exotic drug through media reports pertaining to the [[United Nations]] mission in [[Somalia]], where khat use is widespread, and its role in the [[Persian Gulf]]. The khat plant is known by a variety of names, such as qat in Yemen, chat in [[Ethiopia]], jaad in Somalia and miraa in Kenya and Tanzania.
Khat use has traditionally been confined to the regions where khat is grown, because only the fresh leaves have the desired stimulating effects. In recent years improved roads, off-road motor vehicles and air transport have increased the global distribution of this perishable commodity. Traditionally, khat has been used as a socializing drug, and this is still very much the case in Yemen where khat-chewing is a predominantly male habit.<ref name="Sanaa">[http://news.bbc.co.uk/2/hi/programmes/from_our_own_correspondent/6530453.stm Yemen's khat habit soaks up water] by Alex Kirby. [[bbb.co.uk]]. Written [[2007]]-[[April 7|4-7]]. Accessed [[2007]]-[[April 8|4-8]].</ref> In other countries, khat is consumed largely by single individuals and at parties. It is mainly a recreational drug in the countries which grow khat, though it may also be used by farmers and laborers for reducing physical fatigue and by drivers and students for improving attention. This is similar to the use of the [[coca]] leaf in [[South America]].Women also chew Khat in Yemen. They have their own Saloons for chewing Khat. It is also noted that on weekends, husbands and wives chew Khat. Children start chewing Khat at the age of 10.
Khat is used for its mild euphoric and stimulating effects. It has [[anorectic]] effects. It is used by Christians, Jews, and Muslims, though the [[Ethiopian Orthodox Tewahedo Church]] (along with its [[Eritrean Orthodox Tewahdo Church|Eritrean counterpart]]) has forbidden Christians from using it due to its stimulating effects. In Yemen it is so popular that 40% of the country's water supply goes towards irrigating it, with the percentage increasing by about 10% to 15% every year.<ref name="Sanaa">a</ref> The water supply of [[Sanaa]] is so threatened by the crop that government officials have even proposed relocating large portions of the city's population to the coast of the [[Red Sea]].<ref name="Sanaa">a</ref>
In Somalia, the [[Supreme Islamic Courts Council]], which took control of much of the country in 2006, banned khat during [[Ramadan]], sparking street protests in [[Kismayo]]. In November 2006, Kenya banned all flights to Somalia, citing security concerns, prompting protests by Kenyan khat growers. The Kenyan MP from Ntonyiri, [[Meru North District]] stated that local land had been specialized in khat cultivation, that 20 tons worth US$800,000 were shipped to Somalia daily and that a flight ban could devastate the local economy.<ref>[http://news.bbc.co.u
k/2/hi/africa/6142688.stm "Kenya bans all flights to Somalia"], ''[[BBC News]]'', [[13 November]] [[2006]]</ref> With the surprise victory of the Provisional Government backed by Ethiopian forces in the end of December 2006, khat has returned to the streets of Mogadishu, though Kenyan traders have noted demand has not yet returned to pre-ban levels.<ref> It is widley believed that Somali militia fighters loyal to Mohamed Farrah Aidid were under the influence of khat during the first battle of Mogadishu.[http://news.yahoo.com/s/nm/20070102/od_uk_nm/oukoe_uk_somalia_conflict_khat "Somali Islamists are gone -- so "khat" is back!"], ''[[Reuters]]'', [[2 January]] [[2007]]</ref>
== Chemistry/pharmacology ==
The stimulant effect of the plant was originally attributed to "katin", [[cathine]], a [[phenethylamine]]-type substance isolated from the plant. However, the attribution was disputed by reports showing the plant extracts from fresh leaves contained another substance more behaviorally active than cathine. In 1975, the related alkaloid [[cathinone]] was isolated, and its [[absolute configuration]] was established in [[1978]]. Cathinone is not very stable and breaks down to produce cathine and [[phenylpropanolamine|norephedrine]]. These chemicals belong to the [[phenylpropanolamine|PPA (phenylpropanolamine)]] family, a subset of the [[phenethylamine]]s related to [[amfetamine|amphetamines]] and the [[catecholamine]]s [[epinephrine]] and [[norepinephrine]].<ref>{{cite web|url=http://www.drugs.com/npp/khat.html|title=Complete Khat Info|author=Drugs.com|date=01.01.07}}</ref>
Both of khat's major active ingredients -cathine and cathinone- are phenylalklamines, meaning they are in the same class of chemicals as amphetamines. In fact, cathinone and cathine have a very similar molecular structure to amphetamine.<ref>{{cite web|url=http://apt.rcpsych.org/cgi/content/full/9/6/456|title=Adverse Effects of Khat: A Review}}</ref>
When khat leaves dry, the more potent chemical, cathinone, evaporates within 48 hours leaving behind the milder Schedule IV chemical, cathine. Thus, harvesters transport khat by packaging the leaves and stems in plastic bags or wrapping them in banana leaves to preserve their moisture and keep the cathinone potent. It is also common for them to frequently sprinke the plant with water or use refrigeration during transportation.
When the leaves are chewed, cathine and cathinone are released and absorbed through the mucous membranes of the mouth and the lining of the stomach. The action of cathine and cathinone on the reuptake of epinephrine and norepinephrine has been demonstrated in lab animals, showing that one or both of these chemicals cause the body to recycle these neurotransmitters more slowly, resulting in the wakefulness and insomnia associated with khat use.<ref>{{cite web|url=www.ncbi.nlm.nih.gov/entrez|title=Biochemical Effects of Catha edulis, Cathine and Cathinone on Adrenocortical Functions}}</ref>
Receptors for serotonin show a high affinity for cathinone suggesting that this chemical is responsible for feelings of euphoria associated with chewing khat. In mice, cathinone produces the same types of nervous pacing or repetitive scratching behaviors associated with amphetamines.<ref>{{cite web|url=www.ncbi.nlm.nih.gov/entrez|title=Behavioral Effects of Cathinone}}</ref> The effects of cathinone peak after 15 to 30 minutes with nearly 98% of the substance metabolized into norephedrine by the liver.<ref>{{cite web|url=http://apt.rcpsych.org/cgi/content/full/9/6/456|title=Adverse Effects of Khat: A Review}}</ref>
Cathine is somewhat less understood, being believed to act upon the adrenergenic receptors causing the release of epinephrine and norepinephrine.<ref>{{cite web|url=http://humrep.oxfordjournals.org/content/abstract/del454v1|title=Cathin, an Amphetamine Related Compound, Acts on Mammalian Spermatozoa via Adrenergic Receptors in a Capacitation State-Dependent Manner}}</ref> It has a half-life of about 3 hours in humans.
==Effects==
Khat consumption induces mild [[Euphoria (emotion)|euph
oria]] and excitement. Individuals become very talkative under the influence of the drug and may appear to be unrealistic and emotionally unstable. Khat can induce [[mania|manic]] behaviors and hyperactivity. Khat is an effective [[anorectic]] and its use also results in [[constipation]]. Dilated [[pupil]]s (mydriasis), which are prominent during khat consumption, reflect the sympathomimetic effects of the drug, which are also reflected in increased heart rate and blood pressure. A state of drowsy [[hallucination]]s ([[hypnagogia|hypnagogic hallucination]]s) may result coming down from khat use as well. [[Withdrawal]] [[symptom]]s that may follow prolonged khat use include lethargy, mild [[clinical depression|depression]], [[nightmare]]s, and slight [[tremor]]. Long term use can precipitate the following effects: negative impact on liver function, permanent tooth darkening (of a greenish tinge), susceptibility to ulcers, and diminished sex drive. Khat is usually not an addictive drug, although there are some people who cannot stay without it for more than 4-5 days. They feel tired and have difficulty concentrating.<ref>{{cite web|url=http://www.drugs.com/npp/khat.html|title=Complete Khat Info|author=Drugs.com|date=01.01.07}}</ref>
However, a recent British study found khat to be less dangerous than tobacco and alcohol.<ref>{{cite web|url=http://news.bbc.co.uk/1/shared/bsp/hi/pdfs/31_07_06_drugsreport.pdf|title=Drug classification: making a hash of it?|author=House of Commons}}</ref>
== User population ==
It is estimated that several million people are frequent users of khat. Many of the users originate from countries between [[Sudan]] and [[Madagascar]] and in the southwestern part of the [[Arabian Peninsula]], especially [[Yemen]]. In Yemen, 60% of the males and 35% of the females were found to be khat users who had chewed daily for long periods of their life. The traditional form of khat chewing in Yemen involves only male users; khat chewing by females is less formal and less frequent. In [[Saudi Arabia]], the cultivation and consumption of khat are forbidden, and the ban is strictly enforced. The ban on khat is further supported by the clergy on the grounds that the Qur'an forbids anything that is harmful to the body. This is in sharp contrast to the opinions of the clergy in Yemen. In Somalia, 61% of the population reported that they do use khat, 18% report habitual use, and 21% are occasional users. {{Fact|date=February 2007}}
== Control status ==
===World===
In [[1965]], the [[World Health Organization]] Expert Committee on Dependence-producing Drugs' ''Fourteenth Report'' noted, "The Committee was pleased to note the resolution of the [[Economic and Social Council]] with respect to khat, confirming the view that the abuse of this substance is a regional problem and may best be controlled at that level" [http://www.unodc.org/unodc/en/bulletin/bulletin_1965-01-01_4_page007.html]. For this reason, khat was not Scheduled under the [[Single Convention on Narcotic Drugs]]. In [[1980]] the World Health Organization classified khat as a drug of abuse that can produce mild to moderate psychic dependence.
===Australia===
In [[Australia]], the importation of khat is controlled under the Customs (Prohibited Imports) Regulations. Individual users may apply for several required licenses to import up to 5 kg per month for personal use (primarily immigrants from the Horn of Africa). In 2003, the total number of khat annual permits was 294 and the total number of individual khat permits was 202.
{{quotation|There are two types of import permits. The single use Permit to Import can be used only once and you must request a new permit for each time you wish to import khat. Annual Permits are labeled as such and consist of two pages. Annual Permits allow you to import up to 5 kg once a month for up to twelve months.|{{Fact|date=April 2007}}}}
===Canada===
In [[Canada]], khat is a controlled substance under Schedule IV of the [[Controlled Drugs and Substances Act]] (CDSA). Every person who seeks or obtains the substance with
out disclosing authorization to obtain such substances 30 days prior to obtaining another prescription from a practitioner is guilty of an indictable offence and liable to imprisonment for a term not exceeding eighteen months, where the subject-matter of the offence is a substance included in Schedule IV '''or''' is guilty of an offence punishable on summary conviction and liable for a first offence, to a fine not exceeding one thousand dollars or to imprisonment for a term not exceeding six months, or to both, and for a subsequent offence, to a fine not exceeding two thousand dollars or to imprisonment for a term not exceeding one year, or to both. [http://www.rcmp-grc.gc.ca/crimint/drugs_2002_e.htm#khat] [http://lois.justice.gc.ca/en/C-38.8/229593.html#rid-229600]
===France===
Khat is prohibited in [[France]] as a stimulant.<ref>{{cite web|url=http://www.drugs.com/npp/khat.html|title=Complete Khat Info|author=Drugs.com|date=01.01.07}}</ref>
===Germany===
In [[Germany]], Cathine is a controlled substance, and ownership and sale of the plant is illegal. Similar levels of control exist throughout most other European countries.
===Hong Kong===
In Hong Kong, Cathine & Cathinone are regulated under Schedule 1 of Hong Kong's Chapter 134 ''Dangerous Drugs Ordinance''. It can only be used legally by health professionals and for university research purposes. The substance can be given by pharmacists under a prescription. Anyone who supplies the substance without prescription can be fined $10,000(HKD). The penalty for trafficking or manufacturing the substance is a $5,000,000 (HKD) fine and life imprisonment. Possession of the substance for consumption without license from the Department of Health is illegal with a $1,000,000 (HKD) fine and/or 7 years of jail time.
===Israel===
Khat is still used by some people of Yemeni origins. The leaves, as well as the cathonine extract pill called 'Hagiggat' (a joining of the Hebrew word Hagiga (party), and Gat (khat)), are currently illegal.
===Norway===
Khat is classified as a narcotic drug and is illegal to use, sell and possess. Most users are Somali immigrants and khat is smuggled from [[the Netherlands]] and England.<ref>{{cite web|url=http://www.nova.no/index.gan?objid=11648&subid=0&language=1|title=NOVA paper 1/06|date=16.03.07}}</ref>
===Somalia===
On November 17, 2006 the usage and distribution of khat was made illegal according to Somali Islamists in areas they control.<ref>[http://news.bbc.co.uk/2/hi/africa/6157216.stm]</ref> In Somalia, the [[Supreme Islamic Courts Council]], which took control of much of the country in 2006, banned khat during [[Ramadan]], sparking street protests in [[Kismayo]]. In November 2006, Kenya banned all flights to Somalia, citing security concerns, prompting protests by Kenyan khat growers. The Kenyan MP from Ntonyiri, [[Meru North District]] stated that local land had been specialized in khat cultivation, that 20 tons worth US$800,000 were shipped to Somalia daily and that a flight ban could devastate the local economy.<ref>[http://news.bbc.co.uk/2/hi/africa/6142688.stm "Kenya bans all flights to Somalia"], ''[[BBC News]]'', [[13 November]] [[2006]]</ref> With the surprise victory of the Provisional Government backed by Ethiopian forces in the end of December 2006, khat has returned to the streets of Mogadishu, though Kenyan traders have noted demand has not yet returned to pre-ban levels.<ref>[http://news.yahoo.com/s/nm/20070102/od_uk_nm/oukoe_uk_somalia_conflict_khat "Somali Islamists are gone -- so "khat" is back!"], ''[[Reuters]]'', [[2 January]] [[2007]]</ref>
===Sweden===
As in Norway, khat is classified as a narcotic drug in [[Sweden]] and is illegal to use, sell and possess. According to the police, most users are Somali immigrants and most khat is smuggled in from [[the Netherlands]] and England. For more information, see the [http://www.polisen.se/inter/nodeid=35071&pageversion=1.jsp Swedish police website on khat] (text in Swedish).
===Switzerland===
Khat is prohibited in [[Switzerland]] as a stimulant.<ref>{{cite web|ur
l=http://www.drugs.com/npp/khat.html|title=Complete Khat Info|author=Drugs.com|date=01.01.07}}</ref>
===United Kingdom===
Khat is not a controlled substance in the United Kingdom. Because of this, and because of khat's short shelf life, the UK serves as a main gateway for khat being sent by air to North America.[http://www.cbc.ca/canada/toronto/story/2007/01/26/tor-khat.html]
Khat is used by members of the Somali and Yemeni community (mainly men), which is concentrated in [[London]], [[Birmingham]], [[Bristol]], [[Cardiff]], [[Manchester]] and [[Sheffield]]. It is currently legal, although there are calls from some sections of the Somali community for it to be banned. In the [[United Kingdom|UK]], Cathine and Cathinone are [[Misuse of Drugs Act 1971#Class C drugs|Class C drugs]]. The plant '''''Catha edulis''''' is uncontrolled.
===United States===
In the [[United States]], Cathine is in Schedule IV and cathinone is in Schedule I of the U.S. [[Controlled Substance Act]]. The [[1993]] [[Drug Enforcement Administration|DEA]] rule placing cathinone in Schedule I noted that it was effectively also banning khat:
{{quotation|Cathinone is the major psychoactive component of the plant Catha edulis (khat). The young leaves of khat are chewed for a stimulant effect. Enactment of this rule results in the placement of any material which contains cathinone into Schedule I.}}
In July, 2006, the DEA executed '''Operation Somalia Express''', an 18-month investigation which resulted in the coordinated takedown of a 44-member international trafficking organization responsible for smuggling more than 25 tons of khat (estimated by the DEA to be worth more than $10 million) from the [[Horn of Africa]] to the United States.
The indictment represents the largest khat-trafficking prosecution in United States history.
A large of amount of khat was recently discovered in Smyrna, Delaware. Smyrna police on Friday, March 16, 2007 raided a storage room at Sentinel Self Storage after receiving information that a man was storing illegal drugs at that location. Upon making entry into the room, police say they seized 704¼ pounds of suspected Khat, with an estimated street value of approximately $211,275.<ref>{{cite web|url=http://www.dea.gov/slideshow/july2006.htm|title="2006 in Pictures"|author=DEA}}</ref>
On May 17, 2007 200 lbs. of Khat was found in a self storage facility in Louisville, KY.
==Trivia==
* The word "qat" is well known to [[Scrabble]] players as a way to use the Q when no U is available.
* Smuggling of the plant known as Qat (khat) is the main reason British nationals require consular assistance in Canada. [http://www.fco.gov.uk/servlet/Front?pagename=OpenMarket/Xcelerate/ShowPage&c=Page&cid=1007029390590&a=KCountryAdvice&aid=1013618387099]
== See also ==
[[Qat in Yemen]]
==References==
* {{IUCN2006|assessors=Hilton-Taylor|year=1998|id=34617|title=Catha edulis|downloaded=12 May 2006}}
* "Somali Islamists are gone -- so "khat" is back!", Reuters, January 2 2007
* [[Dale Pendell]], ''Pharmakodynamis: Stimulating Plants, Potions and Herbcraft: Excitantia and Empathogenica'', San Francisco: Mercury House, 2002.
== Notes ==
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==External links==
*[http://www.freshgat.com/servlet/the-38/how-to-chew-khat/Detail How to chew qat]
*[http://news.bbc.co.uk/2/shared/spl/hi/picture_gallery/07/africa_growing_khat/html/1.stm BBC News: In pictures... growing khat]
*[http://www.drugs.com/npp/khat.html Drugs.com, Complete Khat Information]
*[http://www.esquire.com/features/articles/2006/060807_mfe_September_06_Quest__1.html Esquire "High in Hell"]
*[http://www.erowid.org/plants/khat/khat.shtml Erowid Khat Vault]
*[http://www.freshgat.com/servlet/the-template/faq/Page Growing Catha Edulis (Khat)]
*[http://news.bbc.co.uk/2/hi/africa/4145400.stm BBC: Getting to grips with khat in Soma
liland]
*[http://news.bbc.co.uk/1/hi/uk/4615415.stm BBC: Harmless habit or dangerous drug?]
*[http://www.tga.gov.au/docs/html/khatapp.htm Australian Government : Therapeutic Goods Administration Khat Importation Kit]
*[http://www.startribune.com/484/story/577963.html Dozens Arrested Nationwide in Drug Case]
*[http://historyofalcoholanddrugs.typepad.com/alcohol_and_drugs_history/qat/index.html Qat news page] - [[Alcohol and Drugs History Society]] (ADHS)
**[http://historyofalcoholanddrugs.typepad.com/alcohol_and_drugs_history/khat/index.html Khat news page] (ADHS)
*[http://seattletimes.nwsource.com/html/localnews/2003199353_khat15m.html Seattle arrest - Khat and the Somalian community]
*[http://villagevoice.com/news/0647,gardiner,75103,2.html Village Voice article on khat]
[[Category:Amphetamines]]
[[Category:Celastraceae]]
[[Category:Flora of South Africa]]
[[Category:Trees of Africa]]
[[Category:Herbal and fungal stimulants]]